We’re honored to share a powerful new episode featuring Dr. Pierre Gholam, MD, FAASLD, AGAF—Professor of Medicine at Case Western Reserve University and Director of the Hepatobiliary Multidisciplinary Team at University Hospitals Seidman Cancer Center. With clarity and compassion, Dr. Gholam explores the complex and evolving nature of liver cancer, tracing its historical roots in viral hepatitis to today’s sharp rise in cases driven by fatty liver disease and alcohol use. He highlights both the breakthroughs and ongoing challenges in hepatocellular carcinoma (HCC) care—from early tyrosine kinase inhibitors to the promise of immune checkpoint inhibitors—while underscoring the critical need for improved screening strategies. Throughout the discussion, Dr. Gholam emphasizes the central role hepatologists play in managing HCC, from diagnosis to therapy.