Professor Markus Peck-Radosavljevic, MD MBA, is Professor of Medicine and Chairman at the Department of Internal Medicine & Gastroenterology (IMuG) at Klinikum Klagenfurt in Austria. A renowned gastroenterologist and hepatologist, he discusses the importance of understanding risks in medical treatments, clear communication, and considering patient preferences in treatment decisions. Professor Peck addresses challenges in patient selection for clinical trials and the impact on access to innovative treatments. Professor Peck also emphasizes the role of second opinions, the importance of trust in the patient-physician relationship, and the expertise required for state-of-the-art care. He touches on the complexities of information overload and the emerging role of artificial intelligence in healthcare decision-making.