In this latest episode of MedInsights Unleashed, we are delighted to welcome Dr. Paulo Hoff, MD, PhD, Professor of Clinical Oncology at the Department of Radiology and Oncology, University of São Paulo. Dr. Hoff discusses the rising incidence of colorectal cancer in younger populations, highlighting key risk factors including poor diet, sedentary lifestyle, and obesity. He emphasizes the critical importance of beginning regular screening at age 45.

The discussion covers the complete treatment journey, from initial diagnosis through staging—which determines both local and distant tumor spread—to help create optimal treatment plans. Dr. Hoff explains that some patients may require temporary or permanent colostomy procedures.

A significant focus is placed on the emerging total neoadjuvant treatment (TNT) approach, which administers all chemotherapy and radiation before surgery to improve outcomes. The episode concludes by emphasizing the value of collaborative care, bringing together different oncology specialists for comprehensive treatment